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Finally, the mold was transferred to an oven (45 C) and placed for 72 h to for demolding, The pure microneedles (MN), Qu loaded microneedles (Qu/MN) and ZC-MSN loaded microneedles (ZC/MN) were also prepared as control groups follow the same protocol using the corresponding ingredients with the same amounts

Both NF-B signaling and mtROS promote NLPR3 inflammasome assembly, a key driver of neuroinflammation that leads to cleavage of precursor cytokines into biologically active pro-inflammatory cytokines, IL-1 and IL-18 (Blevins et al., 2022)